n,n-Dimethylpiperazine-1-carboxamide → HCID 58204040, compound

HRID 1849124Notes

Reaction equation

HRID 1849124 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH3:23][N:24]([CH3:33])[C:25]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)=[O:26]>>[CH3:23][N:24]([CH3:33])[C:25]([N:27]1[CH2:28][CH2:29][N:30]([C:18]([C:12]2[S:13][C:14]3[CH2:15][CH2:16][O:17][C:8]4[CH:7]=[C:6]([C:4]5[CH:3]=[N:2][NH:1][CH:5]=5)[CH:22]=[CH:21][C:9]=4[C:10]=3[N:11]=2)=[O:19])[CH2:31][CH2:32]1)=[O:26]

Participants

3

Reactant 2

HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58204040HCID 58204040, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with N,N-dimethylpiperazine-1-carboxamide (1.2 equiv) to give 196 (M+1 453.0)

Sources & evidence

ORD record
ord-7770e03c2c7b464c81bafb4a50e3b5bf
Source dataset
uspto-grants-2015_02
Patent number
US08952043B2

Reaction notes

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