HCID 29958541, compound → HCID 58204157, compound

HRID 1849130Notes

Reaction equation

HRID 1849130 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([OH:20])=O)[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH2:23]([N:25]([CH2:31][CH3:32])[C@@H:26]1[CH2:30][CH2:29][NH:28][CH2:27]1)[CH3:24]>>[CH2:23]([N:25]([CH2:31][CH3:32])[C@@H:26]1[CH2:30][CH2:29][N:28]([C:18]([C:12]2[S:13][C:14]3[CH2:15][CH2:16][O:17][C:8]4[CH:7]=[C:6]([C:4]5[CH:5]=[N:1][NH:2][CH:3]=5)[CH:22]=[CH:21][C:9]=4[C:10]=3[N:11]=2)=[O:20])[CH2:27]1)[CH3:24]

Participants

3

Reactant 2

HCID 29958541HCID 29958541, compoundHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58204157HCID 58204157, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (R)-N,N-diethylpyrrolidin-3-amine (1.2 equiv) to give 202 (M+1 438.0)

Sources & evidence

ORD record
ord-a2348a444a534220b2822d2afd722c2b
Source dataset
uspto-grants-2015_02
Patent number
US08952043B2

Reaction notes

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