(3S)-3-(Trifluoromethyl)pyrrolidine → HCID 58203839, compound

HRID 1849138Notes

Reaction equation

HRID 1849138 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[F:23][C:24]([F:31])([F:30])[C@H:25]1[CH2:29][CH2:28][NH:27][CH2:26]1>>[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([N:27]5[CH2:28][CH2:29][C@@H:25]([C:24]([F:31])([F:30])[F:23])[CH2:26]5)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 51514730(3S)-3-(Trifluoromethyl)pyrrolidineHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58203839HCID 58203839, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (S)-3-(trifluoromethyl)pyrrolidine (1.2 equiv) to give 213 (15.8 mg, M+1 435.1)

Sources & evidence

ORD record
ord-897a3fe3cba443409d0165ca8d1babc1
Source dataset
uspto-grants-2015_02
Patent number
US08952043B2

Reaction notes

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