2-Fluoropyridine-3-boronic acid → HCID 58203787, compound

HRID 1849248Notes

Reaction equation

HRID 1849248 reaction equation
Br[C:2]1[S:19][C:5]2[C:6]3[N:14]=[CH:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[CH:11][C:7]=3[O:8][CH2:9][CH2:10][C:4]=2[CH:3]=1.[F:20][C:21]1[C:26](B(O)O)=[CH:25][CH:24]=[CH:23][N:22]=1>>[F:20][C:21]1[C:26]([C:2]2[S:19][C:5]3[C:6]4[N:14]=[CH:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[CH:11][C:7]=4[O:8][CH2:9][CH2:10][C:4]=3[CH:3]=2)=[CH:25][CH:24]=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 27832702-Fluoropyridine-3-boronic acidHCID 67050574HCID 67050574, compound

Product 1

HCID 58203787HCID 58203787, compoundYield 61%

Procedure

Methyl 9-bromo-6,7-dihydrothieno[2,3-d]pyrido[3,2-b]oxepine-3-carboxylate was coupled with 2-fluoropyridin-3-ylboronic acid under Suzuki conditions to give methyl 9-(2-fluoropyridin-3-yl)-6,7-dihydrothieno[2,3-d]pyrido[3,2-b]oxepine-3-carboxylate. Yield 61%. MS(ESI+): 357.1

Sources & evidence

ORD record
ord-8eac6c007c1e4bbbba570b684bb4cdfe
Source dataset
uspto-grants-2015_02
Patent number
US08952043B2

Reaction notes

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