HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (2-hydroxy-ethyl)-isopropyl-amide → HCID 58203905, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (2-hydroxy-ethyl)-isopropyl-amide | HCID 58204002 | — |
| Reactant | (R)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-pyrazol-1-yl)propan-2-ol | HCID 67050615 | — |
| Product | HCID 58203905 | HCID 58203905 | 10% |
Reaction Steps
Following the procedure for 277, 9-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (2-hydroxy-ethyl)-isopropyl-amide (418 mg, 1.02 mmol) and (R)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-pyrazol-1-yl)propan-2-ol (307.4 mg, 1.22 mmol) were reacted to give 369 (44.8 mg, 10% yield, M+1 457.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952043B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8233826052d54cd1b5845a5eaa25bca4 |
| Source note | uspto-grants-2015_02 |