反应详情

温度

0 °C

To a mixture of 8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid N-isopropyl-hydrazide hydrochloride (3.5 g, 8.4 mmol) and TEA (4.07 mL, 29.3 mmol) in DCM (35 mL) at 0° C. was added methoxy-acetyl chloride (1.53 mL, 16.7 mmol) dropwise and the reaction mixture was stirred at 0° C. for 0.75 h then 18 h at RT. The reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution and the phases separated. The aqueous phase was extracted with DCM (×2) before the combined organic extracts were washed with 10% citric acid solution, followed by brine then dried (Na2SO4) and concentrated in vacuo to give a yellow brown solid. The solid was triturated with diethyl ether to give the title compound as an off white solid (2.66 g, 5.86 mmol, 70%). LCMS RT=4.64 min, [M+H]+=454/456.

1. custom18 h
2. customat RT
3. customThe reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution
4. customthe phases separated
5. extractionThe aqueous phase was extracted with DCM (×2) before the combined organic extracts
6. washwere washed with 10% citric acid solution
7. dry with materialthen dried (Na2SO4)
8. concentrationconcentrated in vacuo
9. customto give a yellow brown solid
10. customThe solid was triturated with diethyl ether