Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate → 5-Cyclopropyl-4-((4,4-difluoro-1-methylcyclohexyl)methoxy)-2-fluorobenzoic acid

HRID 1849617Notes

Reaction equation

HRID 1849617 reaction equation
C1(C2C(OCC3(C(F)(F)F)CCCCC3)=CC(F)=C(C=2)C(OC(C)(C)C)=O)CC1.[CH:30]1([C:33]2[C:34]([O:47][CH2:48][C:49]3([CH3:57])[CH2:54][CH2:53][C:52]([F:56])([F:55])[CH2:51][CH2:50]3)=[CH:35][C:36]([F:46])=[C:37]([CH:45]=2)[C:38]([O:40]C(C)(C)C)=[O:39])[CH2:32][CH2:31]1>>[CH:30]1([C:33]2[C:34]([O:47][CH2:48][C:49]3([CH3:57])[CH2:50][CH2:51][C:52]([F:56])([F:55])[CH2:53][CH2:54]3)=[CH:35][C:36]([F:46])=[C:37]([CH:45]=2)[C:38]([OH:40])=[O:39])[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 86703449Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoateHCID 86703471Tert-butyl 5-cyclopropyl-4-((4,4-difluoro-1-methylcyclohexyl)methoxy)-2-fluorobenzoate

Product 1

HCID 867034725-Cyclopropyl-4-((4,4-difluoro-1-methylcyclohexyl)methoxy)-2-fluorobenzoic acid

Procedure

Following the procedure as described in Example 158 step 4, and making variations as required to replace tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate with tert-butyl 5-cyclopropyl-4-((4,4-difluoro-1-methylcyclohexyl)methoxy)-2-fluorobenzoate, the title compound was obtained as a colorless solid (2.74 g, 86%): MS (ES+) m/z 343.2 (M+1).

Sources & evidence

ORD record
ord-b4eace7b26714b0e82dbf315ec0d0c38
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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