Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate → 4-(Cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoic acid

HRID 1849629Notes

Reaction equation

HRID 1849629 reaction equation
[CH:1]1([C:4]2[C:5]([O:18][CH2:19][C:20]3(C(F)(F)F)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:6][C:7]([F:17])=[C:8]([CH:16]=2)[C:9]([O:11]C(C)(C)C)=[O:10])[CH2:3][CH2:2]1.C1(COC2C(C3CC3)=CC(C(OC(C)(C)C)=O)=C(F)C=2)CCCCC1>>[CH:20]1([CH2:19][O:18][C:5]2[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:16][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:17])[CH:6]=2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 86703449Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoateHCID 86703486Tert-butyl 4-(cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoate

Product 1

HCID 867034874-(Cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoic acid

Procedure

Following the procedure as described in Example 158 step 4 and making variations as required to replace tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)-methoxy)benzoate with tert-butyl 4-(cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoate, the title compound was obtained as a colorless solid (6.64 g, 58%): MS (ES−) m/z 291.3 (M−1).

Sources & evidence

ORD record
ord-d87f9a50341342f8a4c4924b2317e41d
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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