Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate → Tert-butyl 5-cyclopropyl-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate

HRID 1849640Notes

Reaction equation

HRID 1849640 reaction equation
ClC1C(OCC2(C(F)(F)F)CCCCC2)=C[C:5](F)=[C:6]([CH:14]=1)C(OC(C)(C)C)=O.Cl[C:29]1[C:30]([O:43][CH2:44][CH:45]2[CH2:50][CH2:49][CH2:48][C:47]([CH3:52])([CH3:51])[CH2:46]2)=[CH:31][C:32]([F:42])=[C:33]([CH:41]=1)[C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35]>>[CH:14]1([C:29]2[C:30]([O:43][CH2:44][CH:45]3[CH2:50][CH2:49][CH2:48][C:47]([CH3:52])([CH3:51])[CH2:46]3)=[CH:31][C:32]([F:42])=[C:33]([CH:41]=2)[C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 86703448Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoateHCID 86703499Tert-butyl 5-chloro-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate

Product 1

HCID 86703501Tert-butyl 5-cyclopropyl-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate

Procedure

Following the procedure as described in Example 158 step 3 and making variations as required to replace tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate with tert-butyl 5-chloro-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate, the title compound was obtained as colorless oil (2.45 g, 75%): MS (ES+) m/z 399.2 (M+23).

Sources & evidence

ORD record
ord-d6262a9a4d3f44818ca9d43997ec0bf8
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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