Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate → 5-Cyclopropyl-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoic acid

HRID 1849641Notes

Reaction equation

HRID 1849641 reaction equation
C1(C2C(OCC3(C(F)(F)F)CCCCC3)=CC(F)=C(C=2)C(OC(C)(C)C)=O)CC1.[CH:30]1([C:33]2[C:34]([O:47][CH2:48][CH:49]3[CH2:54][CH2:53][CH2:52][C:51]([CH3:56])([CH3:55])[CH2:50]3)=[CH:35][C:36]([F:46])=[C:37]([CH:45]=2)[C:38]([O:40]C(C)(C)C)=[O:39])[CH2:32][CH2:31]1>>[CH:30]1([C:33]2[C:34]([O:47][CH2:48][CH:49]3[CH2:54][CH2:53][CH2:52][C:51]([CH3:56])([CH3:55])[CH2:50]3)=[CH:35][C:36]([F:46])=[C:37]([CH:45]=2)[C:38]([OH:40])=[O:39])[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 86703449Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoateHCID 86703501Tert-butyl 5-cyclopropyl-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate

Product 1

HCID 867035025-Cyclopropyl-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoic acid

Procedure

Following the procedure as described in Example 158 step 4, and making variations as required to replace tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate with tert-butyl 5-cyclopropyl-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate, the title compound was obtained as a colorless solid (0.46 g, 22%): MS (ES−) m/z 319.3 (M−1).

Sources & evidence

ORD record
ord-2867bf1bd4334586adc79c3faad24b29
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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