HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid → Tert-butyl 4-(adamantan-2-ylmethoxy)-5-chloro-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid | HCID 86703446 | — |
| Reactant | 4-(Adamantan-2-ylmethoxy)-5-chloro-2-fluorobenzoic acid | HCID 86703507 | — |
| Product | Tert-butyl 4-(adamantan-2-ylmethoxy)-5-chloro-2-fluorobenzoate | HCID 86703506 | — |
Reaction Steps
Following the procedure as described in Example 158 step 2, and making variations as required to replace 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)-methoxy)benzoic acid with 4-(adamantan-2-ylmethoxy)-5-chloro-2-fluorobenzoic acid, the title compound was obtained as a colorless oil (2.13. g, 48%): MS (ES−) m/z 393.2 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d0d6aaa7746b479dab1e22ccdb6b69c9 |
| Source note | uspto-grants-2015_02 |