Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate → Tert-butyl 4-(adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoate

HRID 1849645Notes

Reaction equation

HRID 1849645 reaction equation
ClC1C(OCC2(C(F)(F)F)CCCCC2)=C[C:5](F)=[C:6]([CH:14]=1)C(OC(C)(C)C)=O.[CH:28]12[CH2:37][CH:32]3[CH2:33][CH:34]([CH2:36][CH:30]([CH2:31]3)[CH:29]1[CH2:38][O:39][C:40]1[C:52](Cl)=[CH:51][C:43]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])=[C:42]([F:54])[CH:41]=1)[CH2:35]2>>[CH:28]12[CH2:37][CH:32]3[CH2:33][CH:34]([CH2:36][CH:30]([CH2:31]3)[CH:29]1[CH2:38][O:39][C:40]1[C:52]([CH:14]3[CH2:6][CH2:5]3)=[CH:51][C:43]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])=[C:42]([F:54])[CH:41]=1)[CH2:35]2

Participants

3

Reactant 2

HCID 86703448Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoateHCID 86703506Tert-butyl 4-(adamantan-2-ylmethoxy)-5-chloro-2-fluorobenzoate

Product 1

HCID 86703508Tert-butyl 4-(adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoate

Procedure

Following the procedure as described in Example 158 step 3, and making variations as required to replace tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate with tert-butyl 4-(adamantan-2-ylmethoxy)-5-chloro-2-fluorobenzoate, the title compound was obtained as colorless oil (1.99 g, 92%): MS (E+) m/z 401.3 (M+1).

Sources & evidence

ORD record
ord-3a924a62e6ef415886369a87072ecf81
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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