HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate → 5-Cyclopropyl-4-((4,4-difluorocyclohexyl)-methoxy)-2-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate | HCID 86703449 | — |
| Reactant | Tert-butyl 5-cyclopropyl-4-((4,4-difluorocyclohexyl)methoxy)-2-fluorobenzoate | HCID 86703518 | — |
| Product | 5-Cyclopropyl-4-((4,4-difluorocyclohexyl)-methoxy)-2-fluorobenzoic acid | HCID 86703517 | — |
Reaction Steps
Following the procedure as described in Example 158 step 4, and making variations as required to replace tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate with tert-butyl 5-cyclopropyl-4-((4,4-difluorocyclohexyl)methoxy)-2-fluorobenzoate, the title compound was obtained as a colorless solid (2.29 g, 50%): MS (ES+) m/z 329.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8dae38e3af2647a6ada0025e0110a9c2 |
| Source note | uspto-grants-2015_02 |