HCID 86703527, compound → HCID 86703528, compound

HRID 1849663Notes

Reaction equation

HRID 1849663 reaction equation
ClC1C(OC2C3CC4CC(Cl)(CC2C4)C3)=C[C:5](F)=[C:6]([CH:10]=1)[C:7](O)=O.[Cl:24][C:25]1[C:26]([O:35][CH2:36][C:37]2([C:41]([F:44])([F:43])[F:42])[CH2:40][CH2:39][CH2:38]2)=[CH:27][C:28]([F:34])=[C:29]([CH:33]=1)[C:30]([OH:32])=[O:31]>>[Cl:24][C:25]1[C:26]([O:35][CH2:36][C:37]2([C:41]([F:42])([F:43])[F:44])[CH2:40][CH2:39][CH2:38]2)=[CH:27][C:28]([F:34])=[C:29]([CH:33]=1)[C:30]([O:32][C:6]([CH3:10])([CH3:7])[CH3:5])=[O:31]

Participants

3

Reactant 2

HCID 86703527HCID 86703527, compoundHCID 86703529HCID 86703529, compound

Product 1

HCID 86703528HCID 86703528, compound

Procedure

Following the procedure as described in Example 218 step 2 and making variations as required to replace 5-chloro-4-((5-chloroadamantan-2-yl)oxy)-2-fluorobenzoic acid with 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzoic acid, the title compound was obtained as clear liquid (2.41 g, 99%): MS (ES+) m/z 327.1, 329.1 (M−55).

Sources & evidence

ORD record
ord-04903a81dd444ab1abaa1125a3430a44
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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