Cyclopropanesulfonamide → HCID 178523997, compound

Participants

Reaction Steps

Following the procedure as described in Example 226 step 4, and making variations as required to replace 5-cyclopropyl-4-((4,4-difluoroadamantan-1-yl)methoxy)-2-fluorobenzoic with trans-5-cyclopropyl-2-fluoro-4-((4-(trifluoromethyl)cyclohexyl)-methoxy)benzoic acid and to replace azetidine-1-sulfonamide with cyclopropanesulfonamide, the title compound was obtained (0.15 g, 81%) as a colorless solid: 1H NMR (300 MHz, DMSO-d6) δ 11.82 (s, 1H), 7.12 (d, J=8.3 Hz, 1H), 6.96 (d, J=13.0 Hz, 1H), 3.92 (d, J=6.0 Hz, 2H), 3.12-3.03 (m, 1H), 2.08-1.78 (m, 6H), 1.38-1.10 (m, 9H), 0.93-0.87 (m, 2H), 0.70-0.65 (m, 2H); MS (ES+) m/z 464.1 (M+1); MS (ES−) m/z 462.2 (M−1).

Provenance & Evidence