HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-(adamantan-1-ylmethoxy)-5-cyclopropylnicotinate → 5-Cyclopropyl-2-fluoro-4-((3,5,7-trifluoroadamantan-1-yl)methoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-(adamantan-1-ylmethoxy)-5-cyclopropylnicotinate | HCID 86702923 | — |
| Reactant | Methyl 5-cyclopropyl-2-fluoro-4-((3,5,7-trifluoroadamantan-1-yl)methoxy)benzoate | HCID 86703572 | — |
| Product | 5-Cyclopropyl-2-fluoro-4-((3,5,7-trifluoroadamantan-1-yl)methoxy)benzoic acid | HCID 86703573 | — |
Reaction Steps
Following the procedure as described in Example 150 step 4 and making variations as required to replace methyl 6-(adamantan-1-ylmethoxy)-5-cyclopropylnicotinate with methyl 5-cyclopropyl-2-fluoro-4-((3,5,7-trifluoroadamantan-1-yl)methoxy)benzoate, the title compound was obtained as a colorless solid (0.48 g, quant.): MS (ES−) m/z 397.2 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-cfeb1f6ceefc489f96efd0b3848c96d2 |
| Source note | uspto-grants-2015_02 |