2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 86703675, compound

Participants

Reaction Steps

To a solution of 7,7-difluoro-1-((4-methoxybenzyloxy)methyl)- bicyclo[4.1.0]heptane (2.50 g, 8.90 mmol) in dichloromethane (20 mL) and water (3.0 mL) was added DDQ (3.00 g, 13.3 mmol) at 0° C. The reaction mixture was stirred at the same temperature for 3 hour. Water (1.5 mL) was added followed by sodium sulfate (10 g). The resulting suspension was filtered through a short pad of silica gel column with ethyl acetate in hexanes (30%) to afford the title compound as a colorless liquid (0.90 g, 62%).

Provenance & Evidence