Tert-butyl 4-((2-cyanoadamantan-2-yl)methoxy)-5-cyclopropyl-2-fluorobenzoate → 5-Cyclopropyl-2-fluoro-4-((1-fluorocyclohexyl)methoxy)benzoic acid

Participants

Reaction Steps

Following the procedure as described in Example 332 Step 6 and making non-critical variations to replace tert-butyl 4-((2-cyanoadamantan-2-yl)methoxy)-5-cyclopropyl-2-fluorobenzoate with tert-butyl 5-cyclopropyl-2-fluoro-4-((1-fluorocyclohexyl)-methoxy)benzoate, the title compound was obtained as a colorless solid (0.48 g, 80%): 1H NMR (300 MHz, CDCl3) δ 7.52 (d, J=8.4 Hz, 1H), 6.57 (d, J=12.5 Hz, 1H), 3.98 (d, J=17.9 Hz, 2H), 2.10-1.89 (m, 2H), 1.76-1.51 (m, 6H), 1.39-1.21 (m, 1H), 0.95-0.86 (m, 2H), 0.69-0.59 (m, 2H).

Provenance & Evidence