Ethyl 2-(4-acetamido-2-methyl-1H-indol-1-yl)acetate → [4-Acetylamino-2-methyl-3-(4-oxazol-5-yl-phenylsulfanyl)-indol-1-yl]-acetic Acid
Reaction equation
C([O:3][C:4](=[O:20])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([NH:15][C:16](=[O:18])[CH3:17])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]1[CH3:19])C.[O:21]1[C:25]([C:26]2[CH:31]=[CH:30][C:29]([SH:32])=[CH:28][CH:27]=2)=[CH:24][N:23]=[CH:22]1>>[C:16]([NH:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[C:8]([S:32][C:29]1[CH:28]=[CH:27][C:26]([C:25]3[O:21][CH:22]=[N:23][CH:24]=3)=[CH:31][CH:30]=1)=[C:7]([CH3:19])[N:6]2[CH2:5][C:4]([OH:3])=[O:20])(=[O:18])[CH3:17]Participants
3
Procedure
The title compound was prepared by the method of example 3 using (4-acetylamino-2-methyl-indol-1-yl)-acetic acid ethyl ester and the product of example 2 step (i).
Sources & evidence
- ORD record
- ord-ef7fff90b3d6401292171808f9607f7c
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741360B2
Reaction notes
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