反应详情

温度

0 °C

To a mixture of lithium aluminum hydride (0.74 g, 19.50 mmol) in anhydrous diethyl ether (11 mL) was added a solution of methyl bicyclo[4.1.0]heptane-3-carboxylate (1.00 g, 6.50 mmol) in anhydrous diethyl ether (4.6 mL) at 0° C. The resulting mixture stirred at 0° C. for 0.5 hour. The mixture was slowly quenched with water (1 mL) at 0° C. and warmed to ambient temperature. The mixture was filtered through diatomaceous earth and washed with diethyl ether. The filtrate was concentrated in vacuo to afford the title compound as colorless oil (0.70 g, 85%): MS (ES+) m/z 127.0 (M+1).

1. customThe mixture was slowly quenched with water (1 mL) at 0° C.
2. temperaturewarmed to ambient temperature
3. filtrationThe mixture was filtered through diatomaceous earth
4. washwashed with diethyl ether
5. concentrationThe filtrate was concentrated in vacuo