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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1849841Generated: October 31, 2026

Tert-butyl 4-((1-cyanocyclohexyl)methoxy)-5-cyclopropyl-2-fluorobenzoate → 4-(Adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoic acid

https://huagongshe.com/reaction/1849841

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 4-((1-cyanocyclohexyl)methoxy)-5-cyclopropyl-2-fluorobenzoateHCID 86703715—
ReactantTert-butyl 4-(adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoateHCID 86703727—
Product4-(Adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoic acidHCID 86703728—

Reaction Steps

Following the procedure as described in Example 373 Step 2 making non-critical variations to replace tert-butyl 4-((1-cyanocyclohexyl)methoxy)-5-cyclopropyl-2-fluorobenzoate with tert-butyl 4-(adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoate, the title compound was obtained as a yellow solid (0.65 g, 76%). The solid was carried forward without further purification and analytical characterization.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08952169B2
Source datasetuspto-grants-2015_02
ORD IDord-dd749efc8c884c19a2ba13b0267091db
Source noteuspto-grants-2015_02