HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-((1-cyanocyclohexyl)methoxy)-5-cyclopropyl-2-fluorobenzoate → 4-(Adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-((1-cyanocyclohexyl)methoxy)-5-cyclopropyl-2-fluorobenzoate | HCID 86703715 | — |
| Reactant | Tert-butyl 4-(adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoate | HCID 86703727 | — |
| Product | 4-(Adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoic acid | HCID 86703728 | — |
Reaction Steps
Following the procedure as described in Example 373 Step 2 making non-critical variations to replace tert-butyl 4-((1-cyanocyclohexyl)methoxy)-5-cyclopropyl-2-fluorobenzoate with tert-butyl 4-(adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoate, the title compound was obtained as a yellow solid (0.65 g, 76%). The solid was carried forward without further purification and analytical characterization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-dd749efc8c884c19a2ba13b0267091db |
| Source note | uspto-grants-2015_02 |