Methyl cyclohex-1-ene-1-carboxylate → HCID 86703737, compound

HRID 1849850Notes

Reaction equation

HRID 1849850 reaction equation
C1(C(OC)=O)CCCCC=1.[F:11][C:12]1([F:22])[CH:18]2[CH:13]1[CH2:14][CH2:15][CH:16]([C:19]([O-])=[O:20])[CH2:17]2>>[F:11][C:12]1([F:22])[CH:18]2[CH:13]1[CH2:14][CH2:15][CH:16]([CH2:19][OH:20])[CH2:17]2

Participants

3

Reactant 2

HCID 87647Methyl cyclohex-1-ene-1-carboxylateHCID 86703738HCID 86703738, compound

Product 1

HCID 86703737HCID 86703737, compound

Procedure

Following the procedure as described in Example 342 Step 1 and making non-critical variations to replace methyl cyclohex-1-enecarboxylate with 7,7-difluorobicyclo[4.1.0]-heptane-3-carboxylate, the title compound was obtained as a colorless liquid (0.30 g, 70%): 1H NMR (300 MHz, CDCl3) δ 3.50-3.23 (m, 2H), 2.50-2.25 (m, 1H), 2.15-1.76 (m, 2H), 1.74-0.96 (m, 5H), 0.96-0.54 (m, 1H).

Sources & evidence

ORD record
ord-9ab81c72b6204b1a8433432f1d1c60c2
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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