HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 4-((1-Benzhydrylazetidin-3-yl)methoxy)-5-cyclopropyl-2-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 86703779 | HCID 86703779 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-((1-Benzhydrylazetidin-3-yl)methoxy)-5-cyclopropyl-2-fluorobenzoic acid | HCID 86703780 | — |
Reaction Steps
A mixture of tert-butyl 4-((1-benzhydrylazetidin-3-yl)methoxy)-5-cyclopropyl-2-fluorobenzoate (203 mg) and potassium hydroxide (187 mg) in DMSO (1.7 mL) was stirred at rt for 16 hr. The contents were acidified with 1M NaH2PO4. Solid was collected with filtration, washed with water, and dried under vacuum (171 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-673dcd566d3942148b52ba143552f1eb |
| Source note | uspto-grants-2015_02 |