Methyl 5-chloro-4-((4,4-difluorocyclohexyl)oxy)-2-fluorobenzoate → 5-Cyclopropyl-2-fluoro-4-(spiro[2.5]octan-6-yloxy)benzoic acid

Participants

Reaction Steps

Following the procedure as described in Example 357 Step 6 and making non-critical variations to replace methyl 5-chloro-4-((4,4-difluorocyclohexyl)oxy)-2-fluorobenzoate with methyl 5-cyclopropyl-2-fluoro-4-(spiro[2.5]octan-6-yloxy)benzoate, the title compound was obtained as a colorless syrup that was carried forward without further purification (0.393 g, quant. yield).

Provenance & Evidence