反应详情

To a stirred solution of 1-[2-(4-chlorophenyl)thiazol-5-yl]ethanone (2.38 g, 10 mmol) in methanol (20 ml) at 0° C. is added sodium borohydride (379 mg, 10.5 mmol) in one portion. The resultant solution is allowed to warm to room temperature, and is then stirred at room temperature for 3 hours. The reaction is quenched with saturated aqueous ammonium chloride solution (200 ml) and extracted with chloroform (200 ml). The organic layer is dried over anhydrous magnesium sulfate and concentrated in vacuuo to give desired product as a brown solid (2.32 g)

1. customThe reaction is quenched with saturated aqueous ammonium chloride solution (200 ml)
2. extractionextracted with chloroform (200 ml)
3. dry with materialThe organic layer is dried over anhydrous magnesium sulfate
4. concentrationconcentrated in vacuuo