反应详情

温度

0 °C

To a suspension of 2-(4-chlorophenyl)selenazole-5-carbaldehyde (130 mg, 0.48 mmol) in methanol (5 ml) is added sodium borohydride (19 mg, 0.5 mmol) at 0° C. The reaction mixture is stirred at 0° C. for 0.5 h. The reaction mixture is quenched with aqueous saturated ammonium chloride solution (10 ml), and extracted with dichloromethane (3×25 ml). The combined organic extracts are dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness to give [2-(4-chlorophenyl)selenazol-5-yl]methanol (127 mg).

1. customThe reaction mixture is quenched with aqueous saturated ammonium chloride solution (10 ml)
2. extractionextracted with dichloromethane (3×25 ml)
3. dry with materialThe combined organic extracts are dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customthe filtrate is evaporated to dryness