反应详情

To a suspension of 2-(4-chlorophenyl)thiazole-5-carbaldehyde (3.26 g, 14.6 mmol) in methanol (50 ml) is added the sodium borohydride (568 mg, 15 mmol) portionwise at room temperature. The reaction mixture is stirred at room temperature for 2 h. The reaction mixture is quenched with 50 ml of an aqueous saturated solution of ammonium chloride, extracted with dichloromethane (2×100 ml). The combined organic extracts are dried with magnesium sulphate, filtered and evaporated to dryness to give [2-(4-chlorophenyl)thiazol-5-yl]methanol (3.24 g).

1. customThe reaction mixture is quenched with 50 ml of an aqueous saturated solution of ammonium chloride
2. extractionextracted with dichloromethane (2×100 ml)
3. dry with materialThe combined organic extracts are dried with magnesium sulphate
4. filtrationfiltered
5. customevaporated to dryness