Potassium Phosphate, Tribasic → HCID 59562421, compound

Participants

Reaction Conditions

Reaction Steps

A microwave vial is charged with 4-chloro-2-(4-chlorophenyl)-5-methylpyrimidine (239 mg, 1 mmol), 2,2,6,6-tetramethyl-pyran-3,5-dione (170 mg, 1 mmol), palladium acetate (12 mg, 0.05 mmol), X-Phos (48 mg, 0.1 mmol) and potassium phosphate (424 mg, 2 mmol). 1,2-dimethoxyethane (3 ml) is added and the reaction heated to 150° C., with stirring, for 30 minutes. Silica gel is added to the crude reaction mixture, the solvent is evaporated under reduced pressure and the residue is purified by flash chromatography on silica gel to give 4-[2-(4-chlorophenyl)-5-methylpyrimidin-4-yl]-2,2,6,6-tetramethylpyran-3,5-dione.

Provenance & Evidence