Boron trifluoride → HCID 86710507, compound

Participants

Reaction Steps

At 0° C., ethane-1,2-dithiol (3 mL) and BF3.2HOAc (4.8 mL) were added into a solution of (5-bromo-2-chlorophenyl)(4-(2,2,2-trifluoroethoxy)phenyl)methanone (5.0 g) in dry DCM. The mixture was stirred at room temperature for 12 hours. The mixture was added with saturated Na2CO3 aqueous solution and then extracted with DCM. The organic phases were combined, dried over Na2SO4, and concentrated to obtain the crude product, then the crude product was purified by silica-gel column chromatography (PE/EA=200/1) to obtain 4 g of 2-(5-bromo-2-chlorophenyl)-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3-dithiolane.

Provenance & Evidence