HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylaniline → 2-Aminoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | 6-Bromo-2-chloroquinoline | HCID 12894086 | — |
| Product | 2-Aminoquinoline | HCID 11379 | — |
Reaction Steps
6-Bromo-2-chloroquinoline (250 mg, 1.0 mmol) and N-methylaniline (2 mL) were heated at 120° C. for 16 hours. Extraction from 2M NaOH into DCM and drying on Na2SO4 gave the crude 2-aminoquinoline. This was converted, via Methods 3 and 5, to compound 205 (88 mg, 31%). [M−H]−=277.0 m/z. Activity: B
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957049B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-3bc8e453fa27474196bab6253a9b597d |
| Source note | uspto-grants-2015_02 |