HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Bromo-2-chloroquinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178516702 | HCID 178516702 | — |
| Product | 6-Bromo-2-chloroquinoxaline | HCID 12686408 | 92% |
Reaction Steps
6-Bromo-2-quinoxalinol (631 mg) in POCl3 (6.3 mL) was refluxed for 2 h, then poured onto ice. The solution was neutralized to pH 7 by addition of NH4OH, and the resulting solid collected by filtration. Washing with water and drying in vacuo gave 6-bromo-2-chloroquinoxaline (627 mg, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957049B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-959e8b9643b14653872cfff1b46243c4 |
| Source note | uspto-grants-2015_02 |