HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Bromo-2-chloro-4,8-dimethylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-Bromo-4,8-dimethylquinolin-2(1H)-one | HCID 14570302 | — |
| Product | 6-Bromo-2-chloro-4,8-dimethylquinoline | HCID 14570304 | 93% |
Reaction Steps
This quinolone (410 mg, 1.6 mmol) in POCl3 (5 mL) was refluxed for 2 h, then poured onto ice. The solution was neutralized to pH 7 by addition of NH4OH, and the resulting solid collected by filtration. Washing with water and drying in vacuo gave 6-bromo-2-chloro-4,8-dimethyl-quinoline (407 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957049B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-34920d0619e94c57bd4c4fb0199b612d |
| Source note | uspto-grants-2015_02 |