HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 23094064, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 4905889 | HCID 4905889 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23094064 | HCID 23094064 | 61.8% |
Reaction Steps
2-(4-Iodophenyl)benzimidazole (200 mg, 0.6 mmol) was methylated with iodomethane (180 mg, 1.2 mmol, 2.0 eq.) and NaH (45 mg, 1.8 mmol, 3 eq.) in DMF (3 mL) for 18 h. Dilution with diethyl ether, washing with water, drying over Na2SO4, and chromatography (10→25% EtOAc/hexanes) gave 1-methyl-2-(4-iodophenyl)benzimidazole (124 mg, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957049B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-054d6e2668f24bf1b0a05835b3f690ae |
| Source note | uspto-grants-2015_02 |