Potassium Hydroxide → HCID 68294306, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (E)-ethyl 3-(1-(2-phenoxyethyl)-1H-pyrazol-4-yl)acrylate (0.143 g, 0.5 mmol) in EtOH (6 mL) was added KOH (0.168 g, 3 mmol) in water (2 mL) and the solution was heated at 60° C. for 6 h. The reaction mixture was then evaporated under vacuum and water (10 mL) was added to the residue. This solution was acidified to pH 4 with aqueous 3N HCl and extracted with EtOAc. The organic extracts were washed with water and brine, dried over Na2SO4 and evaporated in vacuo to get the acid (0.117 g, 91%) as a white solid. ES+(M+H)+259

Provenance & Evidence