Hydrochloric Acid → HCID 66514643, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl 1-(biphenyl-4-yl)-2-hydroxyethylcarbamate (608 mg, 1.940 mmol) in MeOH (3 mL) was added HCl (4M in dioxane, 8 mL) at room temperature. The mixture was stirred for 1 hour and concentrated under reduced pressure. The residue was dissolved in DCM (10 mL)/water (1.0 mL) and stirred with NaHCO3 for 1 hour. The mixture was filtered off and rinsed with DCM. The filtrate was dried over sodium sulfate, filtered off and concentrated under reduced pressure providing (S)-2-amino-2-(biphenyl-4-yl)ethanol (171 mg) as a white solid. LCMS m/z 214.2 (M+H)+, Rt 0.58 min.

Provenance & Evidence