Pyrazole → HCID 86730153, compound

Participants

Reaction Steps

(R)-2-methyl-N—((S)-1-(3-methyl-1H-pyrazol-4-yl)ethyl)propane-2-sulfinamide (290 mg, 1.26 mmol) was dissolved in DMF (5 ml) and added dropwise to a solution of Cs2CO3 (458 mg, 1.41 mmol) in DMF (4 ml). The resulting reaction mixture was stirred at room temperature for 15 min. benzylbromide (216 mg, 1.26 mmol) was added and the reaction was stirred at room temperature for 2 h. LCMS shows mostly product with some starting pyrazole. Added another 0.1 ml of BnBr and 135 mg of Cs2CO3. Stirred another 24H at 50° C. The reaction mixture was diluted with EtOAc (300 mL), washed with 4% aqueous NaCl (2×150, 2×50 mL). The combined aq. layers were back extracted with EtOAc (100 ml). The combined organic layers were washed with brine (100 ml), dried over Na2SO4, filtered and concentrated. Silica gel chromatography, EtOAc/heptane 20-80% to give title compound (mix of regioisomers, 150 mg, 0.470 mmol).

Provenance & Evidence