Aluminium lithium hydride → HCID 86730157, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) suspension of (S)-methyl 4-(1-aminoethyl)-3-fluorobenzoate hydrochloride (0.109 g, 0.468 mmol) in THF (15 mL) was added a solution of LAH in THF (2.0 M, 1.05 mL, 2.10 mmol, 4.49 equiv) and the resulting mixture was stirred at 0° C. for 2 h 20 min and at room temperature for 2½ h. The reaction mixture was quenched by addition of a mixture of Na2SO4 decahydrate and Celite (1:1 by weight) until gas evolution ceased. The reaction mixture was filtered, washed with EtOAc. The filtrate was concentrated and used for the next reaction without purification.

Provenance & Evidence