Hydrazine → tert-butyl N-((1S)-1-(hydrazinecarbonyl)ethyl)carbamate

Participants

Reaction Conditions

Reaction Steps

A solution of hydrazine (234 mg, 7.31 mmol, 1.5 equv. in 8 ml of THF) was added to (S)-methyl 2-(tert-butoxycarbonylamino)propanoate (1000 mg, 4.88 mmol, 1.0 equv.), it was stirred in a sealed tube and refluxed (72° C.) overnight (18 hours), the solvent was removed to yield the desired product (880 mg, white solid) in 84% yield.

Provenance & Evidence