3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)- → 5-Chloro-6-(2,2,2-trifluoroethoxy)nicotinaldehyde

Participants

Reaction Conditions

Reaction Steps

To a solution of (5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanol (4.00 g, 16.56 mmol) in EtOAc (15 mL) was added manganese(IV) oxide (16.93 g, 166 mmol). The reaction was heated with microwave at 120° C. for 30 minutes. The mixture was then filtered through a pad of celite, and rinsed with EtOAc. The filtrated was concentrated to give crude product (3.38 g).

Provenance & Evidence