HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86730244, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 86730246 | HCID 86730246 | — |
| Solvent | Carbon Dioxide | HCID 280 | — |
| Product | HCID 86730244 | HCID 86730244 | — |
| Product | HCID 86730245 | HCID 86730245 | — |
Reaction Steps
(4S)-4-methyl-4-phenyl-3-(2-(1-(4-(piperidin-1-yl)phenyl)ethylamino)pyrimidin-4-yl)oxazolidin-2-one (example 141, 51 mg) was resolved on a column (IA 4.6×100 mm) using 45% MeOH in CO2 to give (S)-4-methyl-4-phenyl-3-(2-((S)-1-(4-(piperidin-1-yl)phenyl)ethylamino)pyrimidin-4-yl)oxazolidin-2-one and (S)-4-methyl-4-phenyl-3-(2-((R)-1-(4-(piperidin-1-yl)phenyl)ethylamino)pyrimidin-4-yl)oxazolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957068B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-77968a970383497fb5f05f85b794ea24 |
| Source note | uspto-grants-2015_02 |