HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86730254, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | HCID 86730256 | HCID 86730256 | — |
| Solvent | Carbon Dioxide | HCID 280 | — |
| Product | HCID 86730254 | HCID 86730254 | — |
| Product | HCID 86730255 | HCID 86730255 | — |
Reaction Steps
4-(4-methoxyphenyl)-5,5-dimethyl-3-(2-((S)-1-phenylethylamino)pyrimidin-4-yl)oxazolidin-2-one (example 54, 62 mg) was resolved in on a column (AD-H 4.6×100 mm) with 30% MeOH modified with 0.2% Et2NH in CO2 to give (S)-4-(4-methoxyphenyl)-5,5-dimethyl-3-(2-((S)-1-phenylethylamino)pyrimidin-4-yl)oxazolidin-2-one and (R)-4-(4-methoxyphenyl)-5,5-dimethyl-3-(2-((S)-1-phenylethylamino)pyrimidin-4-yl)oxazolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957068B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-58390fe639214c1ab8e78c15a0d99361 |
| Source note | uspto-grants-2015_02 |