HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1850245Generated: October 27, 2026
Morpholine → 3-(3-Morpholin-4-YL-pyrazin-2-YL)-azetidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1850245
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate | HCID 59351411 | — |
| Product | 3-(3-Morpholin-4-YL-pyrazin-2-YL)-azetidine-1-carboxylic acid tert-butyl ester | HCID 58547373 | 94% |
Reaction Steps
A mixture of 3-(3-chloro-pyrazin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (7) (269 mg, 1.0 mmol) in morpholine was heated by microwave at 160° C. for 2 h. The mixture was concentrated to give the crude compound and which was purified by column chromatography to afford pure product (11) (300 mg, yield 94%) as solid. ESI-MS (M+1): 321 calc. for C16H24N4O3 320.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08957073B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-de35fc1c3c9044e5b3063a860d80c8fe |
|---|
| Source note | uspto-grants-2015_02 |
|---|
