Hydrochloride methanol → HCID 67469066, compound

HRID 1850257Notes

Reaction equation

HRID 1850257 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[NH:8]1[CH2:11][CH:10]([C:12]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 58547389HCID 58547389, compound

Product 1

HCID 67469066HCID 67469066, compoundYield 99.24%

Procedure

A solution of (33) (341 mg, 1.0 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give (34) (260 mg, 0.99 mmol, yield 99.24%).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-50edf21095a742eabc02ecfcd9bd04f5
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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