Hydrochloride methanol → HCID 67997242, compound

HRID 1850263Notes

Reaction equation

HRID 1850263 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19]3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24].CO>>[ClH:24].[NH:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19]3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 58547577HCID 58547577, compound

Product 1

HCID 67997242HCID 67997242, compoundYield 99%

Procedure

A solution of 3-[3-(3-methyl-pyrrolidin-1-yl)-pyrazin-2-yl]-azetidine-1-carboxylic acid tert-butyl ester (43) (191 mg, 0.6 mmol) in 4N HCl/MeOH (13 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give 2-azetidin-3-yl-3-(3-methyl-pyrrolidin-1-yl)-pyrazine hydrochloride (44)

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-633cce6194044abcbbc5bb65a8487521
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

Loading…