Triethylamine → HCID 58546998, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(3-chloro-quinoxalin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (46) (638 mg, 2 mmol, Preparation 14) and piperidin-4-yl-methanol (253 mg, 2.2 mmol) in DMSO (10 mL) was added Et3N (404 mg, 4 mmol). The reaction mixture was stirred at 140° C. in microwave heating for 4 h. The reaction mixture was diluted with water, extracted with EtOAc (30 mL×3). The combined organic extracts were washed with water (30 mL) and brine (30 mL), dried over Na2SO4 and filtered. The filtrate was evaporated in vacuo and the residue was purified by flash column chromatography on silica gel to give (47) (670 mg, 1.68 mmol, yield 84.15%). ESI-MS (M+1): 399 calc. for C17H22N4O 398.

Provenance & Evidence