Hydrochloride methanol → HCID 67469118, compound

HRID 1850265Notes

Reaction equation

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:21]([N:22]3[CH2:27][CH2:26][CH:25]([CH2:28][OH:29])[CH2:24][CH2:23]3)=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:30].CO>>[ClH:30].[NH:8]1[CH2:9][CH:10]([C:12]2[C:21]([N:22]3[CH2:23][CH2:24][CH:25]([CH2:28][OH:29])[CH2:26][CH2:27]3)=[N:20][C:19]3[C:14]([N:13]=2)=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:11]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58546998HCID 58546998, compound

Product 1

HCID 67469118HCID 67469118, compoundYield 99%

Procedure

A solution of (47) (670 mg, 1.68 mmol) in 4N HCl/MeOH (25 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give [1-(3-azetidin-3-yl-quinoxalin-2-yl)-piperidin-4-yl]-methanol hydrochloride (48) (560 mg, 1.67 mmol, yield 99%).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-f7b3b36350124e6692f9ff450a5a38dd
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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