HCID 58547355, compound → HCID 58547445, compound

Participants

Reaction Steps

To a solution of 4-(3-azetidin-3-yl-pyrazin-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (50) (540 mg, 1.7 mmol) in MeOH was added Pd/C (10%, 0.5 g) under nitrogen. The reaction was stirred under hydrogen (30 psi) at RT for 6 h. Filtered to remove Pd/C and concentrated to dryness to give 4-(3-azetidin-3-yl-pyrazin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (51) (502 mg, 1.58 mmol yield 92.9%).

Provenance & Evidence