Hydrochloride methanol → HCID 86660164, compound

HRID 1850269Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([CH:20]3[CH2:23][N:22]([C:24]4[CH:33]=[CH:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[N:25]=4)[CH2:21]3)=[N:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:34].CO>>[ClH:34].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([CH:20]3[CH2:21][N:22]([C:24]4[CH:33]=[CH:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[N:25]=4)[CH2:23]3)=[N:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58547533HCID 58547533, compound

Product 1

HCID 86660164HCID 86660164, compoundYield 98.9%

Procedure

A solution of 4-[3-(1-quinolin-2-yl-azetidin-3-yl)-pyrazin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (53) (346 mg, 0.78 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give the product (54) (294 mg, 0.77 mmol, yield 98.9%).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-9bcc914259b042fe816c40ec36853e8e
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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