HCID 137328646, compound → HCID 137328645, compound

Participants

Reaction Steps

To a solution of 3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-6-chloro-pyridazin-3-yl}-azetidine-1-carboxylic acid tert-butyl ester (62) (843 mg, 1.7 mmol) in MeOH was added Pd/C (10%, 0.5 g) under nitrogen. The reaction was stirred under hydrogen at RT for 6 h, filtered to remove Pd/C and concentrated to dryness to give 3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-pyridazin-3-yl}-azetidine-1-carboxylic acid tert-butyl ester (63) (730 mg, 1.58 mmol yield 92.9%).

Provenance & Evidence