Hydrochloride methanol → HCID 67469074, compound

HRID 1850274Notes

Reaction equation

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[N:13]=[N:14][CH:15]=[CH:16][C:17]=2[N:18]2[CH2:23][CH2:22][CH:21]([C:24](C)(C)[O:25][SiH2]C(C)(C)C)[CH2:20][CH2:19]2)[CH2:9]1)=O)(C)(C)C.[ClH:33].CO>>[ClH:33].[NH:8]1[CH2:9][CH:10]([C:12]2[N:13]=[N:14][CH:15]=[CH:16][C:17]=2[N:18]2[CH2:19][CH2:20][CH:21]([CH2:24][OH:25])[CH2:22][CH2:23]2)[CH2:11]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 137328645HCID 137328645, compound

Product 1

HCID 67469074HCID 67469074, compoundYield 98%

Procedure

A mixture of 3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-pyridazin-3-yl}-azetidine-1-carboxylic acid tert-butyl ester (63) (730 mg, 1.58 mmol) in 4 M HCl/MeOH solution (20 mL) was stirred at RT for 30 min. Then the solvent was evaporated at 40° C. to give [1-(3-azetidin-3-yl-pyridazin-4-yl)-piperidin-4-yl]-methanol hydrochloride (64) (387 mg, 1.56 mmol, 98% yield) as a yellow solid.

Workup

customThen the solvent was evaporated at 40° C.

Sources & evidence

ORD record: ord-dac538b7d976454aa9446a4cf21ad448
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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